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Former EBM I Literature Review Requirements: Oncology topics

This guide has information about the literature review assignment for the Evidence Based Medicine I course at NEOMED.

Breast cancer

  • Comparing trastuzumab to bevacizumab for the treatment of breast cancer
  • Zoledronate versus ibandronate for the treatment of breast cancer
  • Anastrozole versus tamoxifen for the treatment of breast cancer
  • Letrozole versus tamoxifen for treating breast cancer
  • Letrozole versus anastrozole for treating breast cancer

Accelerated approval for new cancer drugs

  • Vemurafenib (formerly PLX4032) for treating metastatic melanoma. Find one randomized control trial comparing this drug to another drug. For your second article, find an article testing PLX4032 on cancer cell lines. Choose a review article of your choice.
  • Crizotinib for treating non-small cell lung cancer. See H. McEwen about the choosing your articles.

Melanoma

  • Ipilimumab and sargramostim compared to ipilimumab for treating metastatic melanoma
  • Nivolumab vs ipilimumab for treating melanoma
  • Nivolumab vs Ipilimumab vs  Nivolumab and Ipilimumab for treating advanced melanoma
  • Vemurafenib vs dabrafenib vs trametinib for treating metastatic melanoma

Lung cancer

  • Comparing gefitinib versus docetaxel in treating non-small-cell lung cancer
  • Comparing vorinostat/paclitaxel to paclitaxel alone for treating non-small-cell lung cancer
  • Comparing vorinostat/carboplatin to carboplatin alone for treating non-small-cell lung cancer
  • Comparing atezolizumab to docetaxel for patients for treating non-small-cell lung cancer

  • Comparing nivolumab to docetaxel for treating non-small-cell lung cancer

  • Comparing atezolizumab and docetaxel for treatment of non-small cell lung cancer

Misc. oncology topics

  • Denosumab versus zoledronic acid for treating bone metastases in advanced cancer
  • Comparing adjuvant sunitinib to sorafenib for treating non-metastatic renal-cell carcinoma
  • Temozolomide vs. Standard PCV for treating high-grade gliomas
  • Comparing the pain intensity and misconceptions among hospice patients with cancer and their caregivers

  • Eicosapentaenoic acid versus aspirin for the prevention of colorectal adenomas

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