Medications & Natural Products Derived from Animals: Arthropods

Akef H, Kotb N, Abo-Elmatty D, Salem S. Anti-proliferative effects of Androctonus amoreuxi scorpion and Cerastes cerastes snake venoms on human prostate cancer cells. J Cancer Prev. 2017;22(1):40-46.

Wilson D, Boyle GM, Mcintyre L, et al. The aromatic head group of spider toxin polyamines influences toxicity to cancer cells. Toxins (Basel). 2017;9(11)

Bordon KC, Wiezel GA, Amorim FG, Arantes EC. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology. J Venom Anim Toxins Incl Trop Dis. 2015;21:43. Open Access article.

Cherniack E. Bugs as drugs, Part 1: Insects: the "new" alternative medicine for the 21st century?. Altern Med Rev. 2010;15(2):124-35.

Cherniack E. Bugs as drugs, part two: worms, leeches, scorpions, snails, ticks, centipedes, and spiders. Altern Med Rev. 2011;16(1):50-8.

Compound Interest website

Compound Interest website

Dardevet L, Rani D, Aziz TA, et al. Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. Toxins (Basel). 2015;7(4):1079-101. Article is available via PubMed Central.

Kievit F, Veiseh O, Fang C, Bhattarai N, Lee D, Ellenbogen R, et al. Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma. ACS Nano. 2010;4(8):4587-94.

Takacs Z, Toups M, Kollewe A, et al. A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci USA. 2009;106(52):22211-6.

Yang S, Xiao Y, Kang D, et al. Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc Natl Acad Sci USA. 2013;110(43):17534-9.

Ratcliffe N, Mello C, Garcia E, Butt T, Azambuja P. Insect natural products and processes: new treatments for human disease. Insect Biochem Mol Biol. 2011;41(10):747-69. Article available via the OhioLINK Electronic Journal Center.

Lee E, Kim JK, Shin S, et al. Insight into the antimicrobial activities of coprisin isolated from the dung beetle, Copris tripartitus, revealed by structure-activity relationships. Biochim Biophys Acta. 2013;1828(2):271-83.

Cai T, Luo J, Meng E, et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels. Peptides. 2014 Sep 10. pii: S0196-9781(14)00273-3. PubMed abstract.

Wang K, Yan J, Liu X, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista. Toxicology. 2011;288(1-3):27-33. Article available to OhioLINK patrons.

Interactive slide show

Leite NB, Aufderhorst-Roberts A, Palma MS, Connell SD, Neto JR, Beales PA. PE and PS lipids synergistically enhance membrane poration by a peptide with anticancer properties. Biophys J. 2015;109(5):936-47.

ScienceDaily

Khamessi O, Ben Mabrouk H, Othman H, et al. RK, the first scorpion peptide with dual disintegrin activity on αβ and αβ integrins. Int J Biol Macromol. 2018;120(Pt B):1777-1788. PubMed abstract.

Ortiz E, Gurrola GB, Schwartz EF, Possani LD. Scorpion venom components as potential candidates for drug development. Toxicon. 2015;93:125-35.

Rogers D. Scorpion venoms: taking the sting out of lung disease. Thorax. 1996;51(5):546-8.

Ding J, Chua PJ, Bay BH, Gopalakrishnakone P. Scorpion venoms as a potential source of novel cancer therapeutic compounds. Exp Biol Med (Maywood). 2014;239(4):387-93.
PubMed abstract

Mamelak A, Jacoby D. 2007. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin Drug Deliv 4(2):175-86. PubMed abstract

Chow CY, Cristofori-Armstrong B, Undheim EA, King GF, Rash LD. Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from the venom of an Australian tarantula. Toxins (Basel). 2015;7(7):2494-513.

Fieck A, Hurwitz I, Kang A, Durvasula R. Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts. Exp Parasitol. 2010;125(4):342-7.

Giovannini C, Baglioni M, Baron Toaldo M, Cescon M, Bolondi L, Gramantieri L. Venom from Cuban Blue Scorpion has tumor activating effect in hepatocellular carcinoma. Sci Rep. 2017;7:44685.

Carcamo-Noriega EN, Sathyamoorthi S, Banerjee S, et al. 1,4-Benzoquinone antimicrobial agents against and derived from scorpion venom. Proc Natl Acad Sci USA. 2019;116(26):12642-12647.

Lozano-Trujillo LA, Garzón-Perdomo DK, Vargas ACR, de Los Reyes LM, Avila-Rodriguez MF, Gay OTG, Turner LF. Cytotoxic Effects of Blue Scorpion Venom (Rhopalurus junceus) in a Glioblastoma Cell Line Model. Curr Pharm Biotechnol. 2021;22(5):636-645. doi: 10.2174/1389201021666200717092207. PMID: 32679017. PubMed abstract

Dioguardi M, Caloro GA, Laino L, Alovisi M, Sovereto D, Crincoli V, Aiuto R, Dioguardi A, De Lillo A, Troiano G, Lo Muzio L. Therapeutic Anticancer Uses of the Active Principles of "Rhopalurus junceus" Venom. Biomedicines. 2020 Sep 27;8(10):382. doi: 10.3390/biomedicines8100382. PMID: 32992456; PMCID: PMC7600222.

ArmstrongConrad P. 2008. Blood collection from the American horseshoe crab, Limulus polyphemus.Blood collection from the American Horseshoe Crab, Limulus polyphemus. J Vis Exp. (20):[No Pagination].

Audubon magazine
By Deborah Cramer
May 11, 2018

Kushibiki T, Kamiya M, Aizawa T, et al. Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide. Biochim Biophys Acta. 2014;1844(3):527-34. PubMed abstract.

from The Atlantic
by Sarah Zhang
May 9, 2018

National Science Foundation Press Release (May 19, 2011)

National Science Foundation

Zimmer J, Hobkirk J, Mohamed F, Browning MJ, Stover CM. On the functional overlap between complement and anti-microbial peptides. Front Immunol. 2014;5:689.

More information about horseshoe crab blood.

LiuPassaglia JSL. 2009. Using the horseshoe crab, Limulus Polyphemus, in vision research.Using the Horseshoe Crab,Limulus Polyphemus, in Vision Research. J Vis Exp. (29):[No Pagination].