Medications & Natural Products Derived from Animals: Ocean Animals

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Bergeron ZL, Chun JB, Baker MR, et al. A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications. Peptides. 2013;49:145-58. Article available via the OhioLINK Electronic Journal Center.

Ayed Y, Dellai A, Ben Mansour H, Bacha H, Abid S. Analgesic and antibutyrylcholinestrasic activities of the venom prepared from the Mediterranean jellyfish Pelagia noctiluca (Forsskal, 1775). Ann Clin Microbiol Antimicrob. 2012;11:15.

Beeton C, Pennington M, Norton R. Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases. Inflamm Allergy Drug Targets. 2011;10(5):313-21.

Rastogi A, Biswas S, Sarkar A, Chakrabarty D. Anticoagulant activity of Moon jellyfish (Aurelia aurita) tentacle extract. Toxicon. 2012;60(5):719-23. Article available to NEOMED patrons via the OhioLINK Electronic Journal Center.

Graça A, Bondoso J, Gaspar H, Xavier J, Monteiro M, et al. Antimicrobial activity of heterotrophic bacterial communities from the marine sponge Erylus discophorus (Astrophorida, Geodiidae). PLoS ONE. 2013;8(11):e78992. Article is freely available.

Otero-González A, Magalhães B, Garcia-Villarino M, L , et al. Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control. FASEB J. 2010;24(5):1320-34.

Zheng L-H, Wang Y-J, Sheng J, et al. Antitumor peptides from marine organisms. Marine Drugs 2011;9(10):1840-1859. Article available in PubMed Central.

Sagar S, Kaur M, Minneman K. Antiviral lead compounds from marine sponges. Mar Drugs. 2010;8(10):2619-38.

Ebada S, Lin W, Proksch P. Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance. Mar Drugs. 2010;8(2):313-46.

Sima P, Vetvicka V. Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Bryozoa, Mollusca, Echinodermata and Urochordata. World J Clin Oncol. 2011;2(11):362-6.

Sima P, Vetvicka V. Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata. World J Clin Oncol. 2011;2(11):355-61.

Finol-Urdaneta R, Remedi M, Raasch W, Becker S, Clark R, Str , et al. Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med. 2012;4(5):424-34.

Zhu F, Qin C, Tao L, Liu X, Shi Z, Ma X, et al. 2011. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A. 2011;108(31):12943-8.

McIntosh J, Jones R. Cone venom--from accidental stings to deliberate injection. Toxicon. 2001;39(10):1447-51.
PubMed abstract of article. It is available online via the OhioLINK Electronic Journal Center.

Moller C, Davis WC, Clark E, De Caprio A, Mari F. Conodipine-P1-3, the first phospholipases A characterized from injected cone snail-venom. Mol Cell Proteomics. 2019;pii: mcp.RA118.000972. [Epub ahead of print]

Lewis RJ, Dutertre S, Vetter I, Christie MJ. Conus venom peptide pharmacology. Pharmacol Rev. 2012;64(2):259-98.

Yu S, Ye X, Chen L, et al. Cytotoxic and anti-colorectal tumor effects of sulfated saponins from sea cucumber Holothuria moebii. Phytomedicine. 2015;22(12):1112-9. (PubMed abstract). Article available to OhioLINK patrons via the Electronic Journal Center.

Chi V, Pennington M, Norton R, Tarcha E, Londono L, Sims-Fahey B, et al. 2012. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012;59(4):529-46. Article is available via OhioLINK's Electronic Journal Center.

Urbarova I, Karlsen B, Okkenhaug S, Seternes O, Johansen S, Emblem A. Digital marine bioprospecting: mining new neurotoxin drug candidates from the transcriptomes of cold-water sea anemones. Mar Drugs. 2012;10(10):2265-79. Article freely available in PubMed Central.

Valeriote F, Tenney K, Media J, Pietraszkiewicz H, Edelstein M, Johnson T, et al. Discovery and development of anticancer agents from marine sponges: perspectives based on a chemistry-experimental therapeutics collaborative program. J Exp Ther Oncol. 2012;10(2):119-34. PubMed abstract. Article is available to NEOMED patrons via EBSCO.

Panda S, Kumari L. Discovery of an unexplored protein structural scaffold of serine protease from big blue octopus (Octopus Cyanea): a new prospective lead molecule. Curr Drug Discov Technol. 2017; [Epub ahead of print].
PubMed abstract

Jeong SH, Kim HK, Song IS, et al. Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs. Mar Drugs. 2014;12(5):2922-36. Article available via PubMed Central.

Yano A, Abe A, Aizawa F, et al. The effect of eating sea cucumberjelly on Candida load in the oral cavity of elderly individuals in a nursing home. Marine Drugs 2013;11(12):4993-5007. Article available in PubMed Central.

Arai M, Yamano Y, Setiawan A, Kobayashi M. Identification of the target protein of Agelasine D, a marine sponge Diterpene alkaloid, as an anti-dormant Mycobacterial substance. Chembiochem. 2014 Jan 3;15(1):117-23.

Tohme R, Darwiche N, Gali-Muhtasib H. A journey under the sea: the quest for marine anti-cancer alkaloids. Molecules. 2011;16(11):9665-96. Article is freely available.

Thomas T, Kavlekar D, LokaBharathi P. Marine drugs from sponge-microbe association--a review. Mar Drugs. 2010;8(4):1417-68. article freely available via PubMed Central.

Kollár P, Rajchard J, Balounová Z, Pazourek J. Marine natural products: bryostatins in preclinical and clinical studies. Pharm Biol. 2014;52(2):237-42. PubMed sbstract.

Blunt J, Copp B, Munro M, Northcote P, Prinsep M. Marine natural products. Nat Prod Rep. 2010;27(2):165-237.
PubMed abstract - article available via the OhioLINK Electronic Journal Center

Gottlieb P, Suchyna T, Ostrow L, Sachs F. 2004. Mechanosensitive ion channels as drug targets. Curr Drug Targets CNS Neurol Disord 3(4):287-95. Article available to affiliated NEOMED library patrons via EBSCO.

De Zoysa M. Medicinal benefits of marine invertebrates: sources for discovering natural drug candidates. Adv Food Nutr Res. 2012;65:153-69. PubMed abstract.

Valle A, Alvarado-mesén J, Lanio ME, Álvarez C, Barbosa JA, Pazos IF. The multigene families of actinoporins (Part I): Isoforms and genetic structure. Toxicon. 2015;

Chang SC, Huq R, Chhabra S, et al. N-terminally extended analogues of the K(+) channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3. FEBS J. 2015;282(12):2247-59.

Deng RH, Zou MZ, Zheng D, et al. Nanoparticles from cuttlefish ink inhibit tumor growth by synergizing immunotherapy and photothermal therapy. ACS Nano. 2019; PubMed abstract.

Russo P, Kisialiou A, Lamonaca P, Moroni R, Prinzi G, Fini M. New drugs from marine organisms in Alzheimer's disease. Mar Drugs. 2015;14(1):5.

Interactive slide show

Mariottini GL, Pane L. The role of Cnidaria in drug discovery. A review on CNS implications and new perspectives. Recent Pat CNS Drug Discov. 2013;8(2):110-22. PubMed abstract.

Burton A. Sea squirt assaults sarcomas. Lancet Oncol. 2002;3(11):648. Available via the OhioLINK Electronic Journal Center.

Dowling MB, MacIntire IC, White JC, et al. Sprayable foams based on an amphiphilic biopolymer for control of hemorrhage without compression. ACS Biomater. Sci. Eng., 2015, 1 (6), pp 440–447.

Shaala L, Youssef D, Sulaiman M, Behery F, Foudah A, Sayed K. Subereamolline A as a potent breast cancer migration, invasion and proliferation inhibitor and bioactive dibrominated alkaloids from the Red Sea sponge Pseudoceratina arabica. Mar Drugs. 2012;10(11):2492-508. Article available via PubMed Central.

Snutch T. Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx. 2005;2(4):662-70.

iBioSeminars

Koopmans M, Martens D, Wijffels R. Towards commercial production of sponge medicines. Mar Drugs. 2009;7(4):787-802. Article in PubMed Central

Monk B, Dalton H, Benjamin I, Tanović A. Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer. Curr Pharm Des. 2012;18(25):3754-69. PubMed abstract

Watters M. Tropical marine neurotoxins: venoms to drugs. Semin Neurol. 2005;25(3):278-89.
PubMed article abstract. Article is available via the OhioLINK Electronic Journal Center.

Sousa SR, Vetter I, Lewis RJ. Venom peptides as a rich source of cav2.2 channel blockers. Toxins (Basel). 2013;5(2):286-314.

Yuk H, Wu J, Sarrafian TL, Mao X, Varela CE, Roche ET, Griffiths LG, Nabzdyk CS, Zhao X. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng. 2021 Aug 9. doi: 10.1038/s41551-021-00769-y. Epub ahead of print. PMID: 34373600. PubMed abstract.