Evidence-based Medicine I Course Guide (Archived): Week 3 9/25/18

EVIDENCE BASED MEDICINE I

WEEK 3

September 25, 2018

ANNOUNCEMENTS:

• Practice questions for Dr. Baughman’s lecture are available in AIMS under Resources folder à Statistics Practice Questions folder.
• Optional Literature Review help session will be held on October 11th at 12 pm in room F-118.
• Optional Peer Writing Tutoring Session - October 12th from 12-1 pm in the Regula Training room. See the Learning Center AIMS site for more information.

UPCOMING ASSESSMENTS:

• Turn in first two assessments via your drop box in the EBM I AIMS site.
• Tertiary Resources Assignment is due at 5 pm on September 25th.
• Literature Review Assignment is due at 5 pm on October 16th.
• Statistics/research design quiz on October 16^th

HOUR 1:

 TOPIC: Introduction to Research Methods / Epidemiology and Descriptive Statistics

 FACULTY: Kristin Baughman, Ph.D.

LEARNING OBJECTIVES:

AT THE END OF THE LECTURE, STUDENTS WILL BE ABLE TO:

• Define and distinguish different study design approaches used in clinical research

• Discuss advantages and disadvantages of different study design approaches
• Distinguish between descriptive and inferential statistics
• List 2 common sampling methods
• Identify data as nominal, ordinal, or interval level
• Describe the normal distribution
• Calculate the mean, median, and mode
• Describe 2 measures of variability

SUPPLEMENTAL READING:  

• Basic & Clinical Biostatistics e-book, Chapters 1 - 3
• Greenhalgh’s How to Read Paper, Chapters 1, 3, and 5

HOUR 2:

TOPIC: Epidemiology and Descriptive Statistics Activity

FACULTY: Kristin Baughman, Ph.D.

LEARNING OBJECTIVES:

AT THE END OF THE LECTURE, STUDENTS WILL BE ABLE TO:

• Calculate and interpret prevalence, incidence, and mortality
• Define 2 measures of population impact
• Calculate and interpret relative risk, odds ratios, absolute risk, number needed to treat
• Distinguish between reliability and validity
• Describe 3 types of internal and external validity

BRING TO CLASS: Your laptop
ASSIGNED READING: None

SUPPLEMENTAL READING:

• Optional: Basic & Clinical Biostatistics e-book, Chapter 3
• Greenhalgh’s How to Read Paper, Chapter 5

CLASS RESOURCES:

• Evidence Based Medicine I course guide
• Example articles:
  • cross-sectional study: Slopen N, Shonkoff JP, Albert MA, Yoshikawa H, Jacobs A, Stoltz R, Williams DR. Racial Disparities in Child Adversity in the US: Interactions with family immigration history and income. Am J Prev Med, 2006, 50(1):47-56. http://scholar.harvard.edu/files/davidrwilliams/files/child_adversity.pdf
  • case- control study: Cannegieter SC, Doggen CJM, van Houwelingen HC, Rosendaal FR (2006) Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study). PLoS Med 3(8): e307. doi: 10.1371/journal.pmed.0030307. http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0030307#s
  • cohort study: Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, et al. (2009) Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study. PLoS Med 6(8): e1000132. doi: 10.1371/journal.pmed.1000132. http://journals.plos.org/plosmedicine/article/asset?id=10.1371/journal.pmed.1000132.PDF
  • qualitative study: Fisher JA, Kalbaugh CA (2012) United States Private-Sector Physicians and Pharmaceutical Contract Research: A Qualitative Study. PLoS Med 9(7): e1001271. doi: 10.1371/journal.pmed.1001271. http://journals.plos.org/plosmedicine/article/asset?id=10.1371/journal.pmed.1001271.PDF
  • diagnosis/screening article: Sabetta JR, Smardin J, Burns L, Barry L, Baisley C, Mahoney T, Travers D, Brennan T, Fontana J, Rabatsky-Ehr T, Cartter ML. Performance of Rapid Influenza Diagnostic Tests During Two School Outbreaks of 2009 Pandemic Influenza A (H1N1) Virus Infection --- Connecticut, 2009. Morbidity & Mortality Weekly Report Sept. 25, 2009/ 58(37): 1029-1032. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5837a1.htm
  • randomized control study: Harding K, Sumner M, Cardinal M. A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers. International Wound Journal, 2013; 10(2): 132-7. http://onlinelibrary.wiley.com/doi/10.1111/iwj.12053/epdf

ASSIGNED READINGS – none

Test Your Knowledge: This class’s material will be covered on Quiz 2 on October 16^th.

DUE TODAY at 5 pm:

• Tertiary Resources Assignment is due at 5 pm on September 25th. Turn in your assignment via your EBM I drop box.